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APOMORPHINE

 APOMORPHINE


BRAND NAME:-Zyprima 2-3mg ,SL tablet etc.



APOMORPHINE is a semisynthetic derivative of morphine; acts as a dopaminergic agonist on the CTZ . Used to treat hypomobile "off" episodes of advanced Parkinson's disease. 



PHARMACODYNAMIC:- 

It is a semisynthetic derivative of morphine; acts as a dopaminergic agonist on the CTZ. Injection i.m./s.c in a dose of 6 mg ,it promptly (within 5 min) induced vomiting. It should not be used if resipration is depressant actions. Oral use of APOMORPHINE is not recommended because the emetic dose is larger ,slow to act and rather inconsistent in action.

Apomorphine has a therapeutic effects in Parkinosonism,but is not used to side effects.


MECHANISM of ACTION:-

Apomorphine is a non-ergoline dopamine agonist with high binding affinity to dopamine D2, D3, and D5 receptors. Stimulation of D2 receptors in the caudate-putamen, a region of the brain responsible for locomotor control, may be responsible for apomorphine's action. However, the means by which the cellular effects of apomorphine treat hypomobility of Parkinson's remain unknown. 


USED:-

used to treat ''off'' episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in people with advanced Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance.

It works by acting in place of dopamine, a natural substance produced in the brain that is needed to control movement. 


Other use these are drug used to evoke vomiting .


SIDE EFFECTS:- 

Redness/swelling/pain/itching at the injection site, nausea, vomiting, headache, sweating, dizziness, drowsiness, yawning, or runny nose may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. 


DOSE:- DIRECT BY PHYSICIAN & HEALTH STAFF.

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