ANTI - HELICOBACTER PYLORI DRUGS

 ANTI - HELICOBACTER PYLORI DRUG 

BRAND COMBINATION AVAILABLE:- 

HP- KIT, HELIBACT ,OMXITIN :-omeprazole 20mg 2 cap + Amoxicillin 750mg 2 tab + tinidazole 500mg 2 tab.

PYLOMOX : Lansoprazole 15mg 2 cap + Amoxicillin 750mg 2tab + Tinidazole 500mg 2 tab .

LANSI KIT :- Lansoprazole 30mg 1 cap+ Amoxicillin 750mg 1 tab + Tinidazole 500mg 1 tab ( one kit twice a day)

PYLOKIT, HELIGO : Lansoprazole 30mg 2cap + Clarithromycin 250mg 2 cap + Tinidazole 500mg 2 tab.

LANPRO AC:- Lansoprazole 30mg 2 cap + Clarithromycin 250mg 2 tab + Amoxicillin 750mg 2 tab .

It is an antimicrobial (triple, quadruple drugs) drug .

Antimicrobial that are used clinically against H.pylori are:- Amoxicillin, Clarithromycin, tetracycline and metronidazole/ Tinidazole. Any single antibiotic is ineffective.

H.pylori is agents used in treatment of Helicobacter Pylori are medicines used for stomach acid inhibition, combined with antibacterial agents. Treatment is for one week with a proton pump inhibitor or an antacid (or antisecretory agents), and two appropriate antibacterial agents. This one week triple therapy does give a good eradication rate. 

PHARMACOLOGY & MECHANISM OF ACTION:-

H.pylori is a gram negative bacillus uniquely adapted to survival in the hostile environment of stomach. It attached to the surface epithelium beneath the mucus, has High urease activity produced ammonia which maintains a neutral microenvironment around the bacteria,and promotes back diffusion OF H+ ions. It has been found as a commensal in 20-70% normal individuals,and is now accepted as an important contributors to the causation of chronic gastritis, dyspepsia,peptic ulcer, gastric lymphoma and gastric carcinoma . H .pylori infection starts with a neutrophilic gastric lasting 7-10days which is usually asymptomatic. Once established,H.pylori generally persists of duodenal and gastric ulcer have tested positive for H. Pylori

 Eradication of H . Pylori concurrently with H2 blocker / PPI therapy of peptic ulcer has been associated with faster ulcer healing and largely prevents ulcer relapse. All H.pylori positive ulcer patients should receive H.pylori eradication therapy. In the absence of H. Pylori testing,all cases with failed conventional ulcer therapy and relapse cases must be given the benefits of H.pylori eradication.

Antimicrobial that are used clinically against H.pylori are:- Amoxicillin, Clarithromycin, tetracycline and metronidazole/ Tinidazole. Any single antibiotic is ineffective. Resistance develops rapidly, especially to metronidazole/ tinidazole and Clarithromycin,but Amoxicillin resistance is infrequent. In tropical countries, metronidazole resistance is more common than Clarithromycin resistance. Since bismuth (CBS) is active against H. pylori and resistance does not develop to it , combination regimens including bismuth may be used in case of metronidazole and Clarithromycin double resistance. Routine use of CBS is precluded by poor patient acceptability. Acid supression by PPIs/H2 blockers enhances effectiveness of anti -H . Pylori anti biotics, and optimum benefits are obtained when gastric pH is kept > 5 for at least 16-18 hours per day . This is a higher degree of round - the - clock acid supression than is needed for duodenal ulcer healing or for reflux esophagitis. Only twice daily PPI dosing can achieve this degree of acid supression. The PPIs benefits by altering the acid environment for H. Pylori as well as by direct inhibitory effects. One of the PPIs is an integral component of all  anti-H .pylori regimens along with 2 (triple) or 3 (quadruple) drugs antimicrobials. 

USED:- in Helicobacter pylori infection ,lower ulcer disease prevalence and prevention of gastric carcinoma/Lymphoma etc.

DOSE:- 1 weeks - twice daily 

2 weeks -Twice daily.

Mainly treatment course are 14 days 

SIDE EFFECTS:-

Mainly diarrhoea & stomach cramps or other.