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ANTHRAQUINONES

 ANTHRAQUINONES


BRAND NAME:- GLAXENNA 11.5 mg tab; PURSENNID 18mg tab; SOFSENA 12mg tab.



ANTHRAQUINONES (also known as anthraquinonoids) are a class of naturally occurring phenolic compounds based on the 9,10-anthraquinone skeleton, are the plant products Used in household/ traditional medicine for centuries.


PHARMACODYNAMIC & FUNCTION:-

senna is obtained from leaves and pods of certain cassia sp., While Cascara sagrada is the powdered bark of the buck - thorn tree. These and a number of other plant purgatives contain ANTHRAQUINONES glycosides, also called emodins. Senna is most popularly used. The glycosides are not active as such . Unabsorbed in the small intestine,they passed to the colon where bacteria liberate the active anthrol from ,which either acts locally or is absorbed into circulation excerted in bile to act on small intestine. Thus they take 6-8 hours produce action . Taken by lactating mothers,the amount secreted in milk is sufficient to cause purgation in the suckling infant.


MECHANISM OF ACTION:-

The purgative action and uses of ANTHRAQUINONES are quite similar to those of diphenylmethanes . Taken at bed time - a single dose,soft but formed evacuation generally occurs in the morning. Cramps and excessive purging of these drugs acts on the myenteric plexus to increase peristalsis and decrease segmentation. They also promote secertion and inhibits salt and water absorption in the colon. Senna anthraquinones has been found to stimulate PGE2 production in rat intestine. This is prevented by indomethacin and the purgative action is reduced.



USE:- as a laxative, antimicrobial and anti-inflammatory agents ,Current therapeutic indications include constipation, arthritis, multiple sclerosis, and cancer.


SIDE EFFECTS:- skin redness, rashes, fixed drug eruption are the occasional adverse effects. Regular use for 4-12 months causes colonic atony and mucosal pigmentation ( melanosis). 


DOSE:- DIRECT BY PHYSICIAN 

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