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Know details about ANIDULAFUNGIN drug ?

 ANIDULAFUNGIN 

BRAND NAME:- ECALTA 50mg/vial, 100mg/vial etc many other brands available in India.

ANIDULAFUNGIN is an anti-fungal drug & are the other echinocandins with similar properties. It was previously known as LY303366. 


PHARMACODYNAMIC:-

Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibits the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls. Anidulafungin is active in vitro against many Candida, as well as some Aspergillus. Like other echinocandins, anidulafungin is not active against Cryptococcus neoformans, Trichosporon, Fusarium, or zygomycetes. 

MECHANISM OF ACTION:-

Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3-β-D-glucan, an essential component of the fungal cell wall, ultimately leading to osmotic instability and cell death. 

USED:-

Treatment of fungal infection including candidemia (fungal infection in the blood), candida peritonitis and abscess (fungal infection in the stomach), esophageal candidiasis (fungal infection in the esophagus), and other fungal infections (including infections in the stomach).


SIDE EFFECTS:-

Main side is affected in liver & others.


DOSE:- 

Adult:-

Day 1: 200 mg IV infusion, THEN

Day 2 and thereafter: 100 mg/day IV

Generally continue 14 days after last positive culture 


Pediatrics:-

Day 1: 3 mg/kg (not to exceed 200 mg/dose) IV infusion, THEN

Day 2 and thereafter: 1.5 mg/kg (not to exceed 100 mg/dose) IV

Generally continue 14 days after last positive culture.

As directed by your doctor.

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