Skip to main content

ANASTROZOLE

To ANASTROZOLE


BRAND NAME:- ALTRAZ,ARMOTRAZ ,ANABREZ 1mg tab.



ANASTROZOLE   another nonsteroidal and reversible (type 2) aromatase inhibitors (AI) , more potent than letrozole and suitable from single daily dosing. 


ACTION:-

Anastrozole is an aromatase inhibitor. It works by lowering the amount of estrogen (natural female hormone) produced in the body. This can lower or stop the growth of some breast cancer cells that need estrogen to grow. It accumulates in the body to produce peak effects after 7-10 days . Anastrozole is useful as adjuvant therapy in early ER+ I've breast cancer as well as for palliation of advanced cases in postmenopausal women. In early cases, tumor recurrence time was found to be longer than with tamoxifen. Risk of new tumor appearing in the contralateral breast was also lower with anastrozole. A longer time to disease progression compared to tamoxifen has been obtained in advanced ER + ve breast cancer.

Many tamoxifen resistance cases responded with increased survival. Like letrozole,it is also a first line drug for early as well as advance breast carcinoma in postmenopausal women.


USED:-

Anastrozole is used in the treatment of breast cancer. It is used with other treatments such as surgery or radiation to treat breast cancer in women who have attained menopaus. 


SIDE EFFECTS:-

 hot flushes, vaginal dryness, vaginal Bleeding,nausea, diarrhoea,tinning of hair. 

Arthralgia and acceleration of osteoporosis are prominent.

However,it does not predispose to endometrial carcinoma or to venous thromboembolism.


DOSE:- 1 mg OD.






Labels:

Comments

Post a Comment

Popular posts from this blog

Know details about Dabigatran etexilate drug ?

 Dabigatran Etexilate 
Post a Comment
Read more

Chlorthalidone Uses, Side Effects, and More....

 Chlorthalidone  Brand name:- Hythalton 50,100mg , Hydrazide, Thalizide ( 12.5, 25) . Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Pharmacodynamic:- Not 🚫 available.  Pharmacokinetics:- Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. As with other thiazide diuretics, ch...
Post a Comment
Read more

Captopril Uses, Side Effects, and More

 Captopril Brand name:- Angiopril 25mg tab, Aceten, Captopril 12.5, 25mg tab. Captopril is an angiotensin converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently. Pharmacodynamic:-  Captopril, an ACE inhibitor, antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons w...
Post a Comment
Read more