ANAKINRA

 ANAKINRA

BRAND NAME:- kineret & others brand available in India.

ANAKINRA is a recombinant human IL -1 receptors antagonist. Though clinically less effective than TNF inhibitors,it has been used in cases who have failed on one or more DMARDs. 

PHARMACODYNAMIC:-

stimulated macrophages and other mononuclear cells elaborate IL-1 which activated helper T-cells and induces production of other ILs, metalloproteinases ,etc. An endogenous IL-1 receptor antagonist has been isolated and several of its recombinant variants have been produced for clinical use.

MECHANISM OF ACTION:-

This recombinant human IL -1 receptors antagonist prevents IL-1 binding to its receptors and has been approved for use in refractory rheumatoid artritis not controlled MTx has been used alone as well as added to TNFalpha antagonist, because it's clinical efficacy as monotherapy appears to be lower.

USE:- treatment of rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease.

SIDE EFFECTS:- Local reaction and chest infection are the main side effects.

DOSE:- 100mg s.c. daily.