Skip to main content

AZATHIOPRINE : used, Side effects, Dose,Pharmacodynamic & mechanism of action...

 AZATHIOPRINE 


BRAND NAME:-IMURAN, TRANSIMUNE ,AZOPRINE 50mg tab . 

AZATHIOPRINE is a antiproliferative & cytotoxic immunosuppressant drug.It reduces the action of body's own defense system (the immune system) and prevents rejection of the transplanted organ. It also blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain joint diseases.

Pharmacodynamic:-

Azathioprine is an immunosuppressive agent which functions through modulation of rac1 to induce T cell apoptosis, as well as other unknown immunosuppressive functions. It has a long duration of action as it is given daily, and has a narrow therapeutic index.Patients should be counselled regarding the risk of malignancies of the skin and lymphomas.

Mechanism of action:- 

 It is a purine antimetabolite which has more marked immunosuppressant than antitumour action . The basis for this difference is not clear, but may be due to its selective uptake into immune cells and intracellular conversion to the active metabolite 6-mercaptopurine, which then undergoes further transformations to inhibit de novo purine synthesis and damage to DNA . It selectively affects differentiation and function of T cells and inhibits cytolytic lymphocyte; CMI is primarily depressed. 

Dose:- 

Azathioprine 3-5mg/kg/day, maintenance 1-2mg /kg/day; as directed by your doctor.


Used :- 

To prevent organ rejection in people who have received a kidney transplant. It is usually taken along with other medications to allow your new kidney to function normally. Azathioprine is also used to treat rheumatoid arthritis. In this condition, the body's defense system (immune system) attacks healthy joints. Azathioprine belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help your body accept the new kidney as if it were your own (in the case of an organ transplant) or to prevent further damage to your joints (in the case of rheumatoid arthritis).Talk to your doctor about the risks and benefits of azathioprine, especially when used by children and young adults.

SIDE EFFECTS:-

The more common side effects that occur with azathioprine include:

•low white blood cell counts

•Infections

•Stomach problems, including nausea, diarrhea, and vomiting 


WARNING ⚠️:-Azathioprine may cause a rare type of lymphoma (cancer) of the liver, spleen, and bone marrow that can be fatal. This has occurred mainly in teenagers and young men with Crohn's disease or ulcerative colitis.












Labels:

Comments

Post a Comment

Popular posts from this blog

Chlorthalidone Uses, Side Effects, and More....

 Chlorthalidone  Brand name:- Hythalton 50,100mg , Hydrazide, Thalizide ( 12.5, 25) . Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Pharmacodynamic:- Not 🚫 available.  Pharmacokinetics:- Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. As with other thiazide diuretics, ch...
Post a Comment
Read more

Chlordiazepoxide Uses, Side Effects, and More

 Chlordiazepoxide Brand name:- Librium 10, 25 mg tabs; Equilibrium 10mg tab. Chlordiazepoxide is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain. Pharmacodynamic:-  Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dos...
Post a Comment
Read more

Know details about Dabigatran etexilate drug ?

 Dabigatran Etexilate 
Post a Comment
Read more