Skip to main content

ATROPINE

 ATROPINE


BRAND NAME:-ATROP inj.Tropine injection.



Atropine is a tropane alkaloid , anticholinergic and antimuscarinic drug.Medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery.

That works through competitive inhibition of postganglionic acetylcholine receptors and direct vagolytic action, which leads to parasympathetic inhibition of the acetylcholine receptors in smooth muscle.

educe salivation and bronchial secretions before surgery or as an antidote for overdose of cholinergic drugs or mushroom poisoning. Atropine may be used alone or with other medications.


Atropine belongs to a class of drugs called Anticholinergic, Antispasmodic Agents.



A-V BLOCK:-


The definitive treatment of chronic heart block is pacing with an 

Implanted cardiac pacemaker. Drugs are of value only for acute/transient A-V block and as an interim measure . When A-V block is due to vagal overactivity ,e.g . digitalis Toxicity,same cases of MI ; it can be improved by atropine 0.6-1.2mg i.m . ATROPINE abbreviates A-V node ERP and increase conduction velocity in bundle of His . 


SYMPATHOMIMETICS:- (Adr,isoprenaline): These drugs may overcome partial heart block by facilitating A-V conduction and shortening ERP of conducting tissues.

They may also be Used in complete (3rd degree) heart block to maintain a sufficient idioventricular rate (by  increasing automatically of ventricular pacemakers) till external pacemaker can be implanted.



SIDE EFFECTS:-Atropine may cause serious side effects including:


fast heartrate,

high pressure in the eye (glaucoma),

abdominal blockage (pyloric obstruction),

worsening urinary retention, and

mucus in your airways (viscid bronchial plugs)

Get medical help right away, if you have any of the symptoms listed above.

dry mouth,

blurred vision,

sensitivity to light,

lack of sweating,

dizziness,

nausea,

loss of balance,

hypersensitivity reactions (skin rash), and

rapid heartrate

Tell your doctor if you have any side effect that bothers you or that does not go away.


These are not all the possible side effects of Atropine. For more information, ask your doctor or pharmacist.


USED:-atropine injection multiple use:-

Anticholinesterase Poisoning,Bradyarrhythmia,Organophosphate Poisoning,Radiographic Exam,Rhinorrhea,Zollinger-Ellison Syndrome,AV Heart Block,Head Injury,Peptic Ulcer,Peptic Ulcer with Hemorrhage,Peptic Ulcer with Hemorrhage and Perforation,Peptic Ulcer with Perforation,Peptic Ulcer with Hemorrhage and Obstruction,Peptic Ulcer with Perforation and Obstruction,Peptic Ulcer with Hemorrhage/Perforation/Obstruction,Peptic Ulcer with Obstruction,Head Injury with Loss of Consciousness,Head Injury with Intracranial Hemorrhage

Head Injury w/ Intracranial Hemorrhage and Loss of Consciousness

CNS Disorder

Nerve Agent Poisoning.


DOSE:- directed by physician 



:In national essential medicine (2011), INDIA(I)


: including in WHO model list of essential medicine March 2011(WHO)



———————————————————————————————


ATROPINE METHONITRATE 


BRAND NAME:- MYDRINDON 1 mg ,0.1 mg tab ; SPASMOLYSIN 0.32mg tab; 



DOSE:- 2.5-10mg oral, i .m .


USED:- for abdominal colics and hyperacidity.





Labels

Labels:

Comments

Post a Comment

Popular posts from this blog

BOTULINUM TOXIN Uses, Side Effects, and More

 BOTULINUM TOXIN ( A or B ) BRAND NAME:- BOTOX ,DYSPORT  BOTULINUM TOXIN  A and B are highly potent exotoxins produced by Clostridium botulinum that are responsible for ' botulism' ( a type of food poisoning). These neurotoxic proteins cause long- lasting loss of cholinergic transmission by interacting with axonal proteins involved in exocytotic release of Ach. Localized injection of minute quantity of botulinum toxin.  PHARMACODYNAMIC :- Botulinum toxin A inhibits the release of acetylcholine, relieving muscle contraction and spasm associated with many conditions, such as incontinence and dystonia. Cosmetically, botulinum toxin A paralyses muscles in the face to temporarily treat wrinkles. The maximum effects of muscle paralysis occur four to seven days after a dose.When injected at therapeutic doses, botulinum toxin A causes partial chemical denervation of muscle tissue, causing local reduction of muscle activity. Muscle atrophy may result, axonal sprouting may beg...
Post a Comment
Read more

Clonazepam used, Side effects, Dose, & more

Clonazepam  Brand name:- Lonazepam , Clonapax , Rivotril 0.5, 1.0, 2.0 mg tab. Clonazepam is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain. Pharmacodynamic:- The pharmacodynamic properties of clonazepam are common among benzodiazepines and include anticonvulsive, sedative, muscle relaxing and anxiolytic effects . Animal data and electroencephalographic investigations in man have shown that clonazepam rapidly suppresses many types of paroxysmal activity including the spike and wave discharge in absence seizures (petit mal), slow spike wave, generalized spike wave, spikes with temporal or other locations, as well as irregular spikes and waves Label . Moreover, the agent can also decrease the frequency, amplitude, duration, and spread of discharge in minor motor seizures Label . Generalized EEG abnormalities are more readily suppressed by clonazepam than are focal ...
Post a Comment
Read more

CLOMIPHENE CITRATE Uses, Side Effects, and More

 CLOMIPHENE CITRATE BRAND NAME:- CLOMIPHENE, FERTOMED, CLOFERT, CLOME 25,50,100mg tab.  Clomiphene is a selective estrogen receptor modulator (SERM) which treats female infertility. It works by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation). PHARMACODYANIMCS:- Clomifene (previously clomiphene) is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM). Clomifene can lead to multiple ovulation, and hence increase the risk of conceiving twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer and weight gain. Clomifene is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracel...
Post a Comment
Read more