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ATORVASTATIN

 ATORVASTATIN


BRAND NAME:-AZTOR,ATORVA,ATORLIP 5.10,20mg tabs.


ATORVASTATIN these are drug which lower the levels of lipids and lipoproteins in blood, it is aHMG-CoA REDUCAASE Inhibitors (statins),the hypolipidaemic drugs have attracted considerable attention because of their potential to prevent cardiovascular disease by regarding the accelerated atherosclerosis in hyperlipidemic individual.

Atorvastatin is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment.

The newer and most popular statin is more potent and appears to have the highest LDL-CH lowering efficacy at maximal daily dose of 80 mg. At this dose a greater reduction in TGs is noted if the same was raised at baseline. ATORVASTATIN has a much longer plasma t½ of 18-24 hr than other stains ,and has additional antioxidant property.


MECHANISM OF ACTION:- 

↓CH synthesis by inhibition of rate limiting HMG-CoA reductase 



EFFECT ON LIPIDS(%)

LDL ↓ 20-55

HDL ↑ 5-15

TG↓ 10-35


DOSE:- 19-40mg/day(max.80mg)



USE:- 

Atorvastatin is used in the treatment of high cholesterol. 


SIDE EFFECTS:-

Indigestion, Diarrhea, Joint pain, Nasopharyngitis (inflammation of the throat and nasal passages), Nausea, Pain in extremities, Urinary tract infection, Abnormal liver function tests. 


:In national essential medicine (2011), INDIA(I)



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