ATORVASTATIN
BRAND NAME:-AZTOR,ATORVA,ATORLIP 5.10,20mg tabs.
ATORVASTATIN these are drug which lower the levels of lipids and lipoproteins in blood, it is aHMG-CoA REDUCAASE Inhibitors (statins),the hypolipidaemic drugs have attracted considerable attention because of their potential to prevent cardiovascular disease by regarding the accelerated atherosclerosis in hyperlipidemic individual.
Atorvastatin is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment.
The newer and most popular statin is more potent and appears to have the highest LDL-CH lowering efficacy at maximal daily dose of 80 mg. At this dose a greater reduction in TGs is noted if the same was raised at baseline. ATORVASTATIN has a much longer plasma t½ of 18-24 hr than other stains ,and has additional antioxidant property.
MECHANISM OF ACTION:-
↓CH synthesis by inhibition of rate limiting HMG-CoA reductase
EFFECT ON LIPIDS(%)
LDL ↓ 20-55
HDL ↑ 5-15
TG↓ 10-35
DOSE:- 19-40mg/day(max.80mg)
USE:-
Atorvastatin is used in the treatment of high cholesterol.
SIDE EFFECTS:-
Indigestion, Diarrhea, Joint pain, Nasopharyngitis (inflammation of the throat and nasal passages), Nausea, Pain in extremities, Urinary tract infection, Abnormal liver function tests.
:In national essential medicine (2011), INDIA(I)
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