ATENOLOL / S(-) ATENOLOL

 ATENOLOL

BRAND NAME:-BETACARD ,ATEN,TENORIM 25,50,100mg tab.

Atenolol is a beta blocker having low lipid solubility.All beta blockers, irrespective of associated properties,exert similar antihypertensive effects.Drugs with intrinsic sympathomimetic activity (ISA) cause less/no reduction of HR and c.o. but lower vascular resistance by Beta2 agonism. 

 Medication primarily used to treat high blood pressure and heart-associated chest pain. Atenolol, however, does not seem to improve mortality in those with high blood pressure. Other uses include the prevention of migraines and treatment of certain irregular heart beats.  

ATENOLOL is Cardioselectivity  drug , these are more potent in blocking cardiac Beta1 than bronchial Beta2 receptors. 

CARDIOSELECTIVITY:-

These drug are more potent in blocking cardiac Beta1 than bronchial Beta2 receptors. Selectivity is only relative and is lost at high doses. 

Their features are:-

1. Lower propensity to cause bronchoconstriction,but even these drug should usually be avoided in asthmatic and COPD patients.

2. Less Interference with carbohydrates metabolism and less inhibition of glycogenolysis during hypoglycemia --safer in diabetics.

3. Lower incidence of cold hand and feet ,less chances of precipitation Raynaud's phenomenon.

4.No/less deleterious effects on blood lipid profile.

5. Ineffective in suppression essential tremor.

6. Less liable to impair exercise capacity.

MECHANISM AND PHARMACOLOGICAL ACTION:-

A relatively selective Beta1 blocker having low lipid solubility. It is in completely absorbed orally,but first pass METABOLISM is not significant. Because of longer duration of action, once daily dose is often sufficient. Side effects related to CNS action are less likely. No deleterious effects on lipid profile have been noted. Effective dose for most individuals falls in a narrow rang . It is one of the most commonly used Beta blockers for hypertension and angina .

DOSE:- 12.5-50mg OD 

USE:-

Atenolol is used in the treatment of Hypertension (high blood pressure), Angina (heart-related chest pain), Arrhythmia and heart attack. 

SIDE EFFECTS:-

Fatigue, Slow heart rate, Cold extremities, Gastrointestinal disturbance. Related to CNS action are less likely.

: In national essential medicine (2011), INDIA(I)

: including in WHO model list of essential medicine March 2011(WHO

-----------------------------------------------------------------------------------------------------

S(-) ATENOLOL

BRAND NAME:- ATPURE,ADBETA 12.5,25,50mg tab.

S(-) ATENOLOL this pure active ENANTIOMER is effective at half the dose and may be better tolerated.

DOSE:- 12.5-50 mg OD;