ATAZANAVIR (ATV)

 ATAZANAVIR(ATV)

BRAND NAME:- ATAZOR 100,150,200,300mg caps.

ATAZANAVIR is an antiviral and retroviral protease inhibitors (PIs) drug.

An aspartic protease enzyme enclosed by HIV is involved in the production of structural proteins and enzymes of the virus from the large viral polyprotein synthesized in the infected cell. The polyprotein is broken into various functional components by the protease enzyme. It acts at a let step in HIV replication, i.e maturation of the new virus particles when the RNA genome acquires the core proteins and enzymes.

PHARMACOLOGICAL & MECHANISM OF ACTION:-

This PIs  is administered with light meal which improve absorption, while acid suppressant drugs decrease it's absorption. ATV is primarily metabolized by CYP3A4, which is also moderately inhibited by it. Bioavailability and efficacy of ATV is improved by combining with RTV . The t½ is 6-8 hours. Dyslipidaemia and other metabolic complicated are minimal with ATV , but jaundice occurs in some patients with out liver damage due to inhibition of hepatic glucuronyl transferse .

USED:-

is used with other HIV medications for infants and children to help control HIV infection. It helps to decrease the amount of HIV in the body so your child's immune system can work better. This lowers the chance of getting HIV complications (such as new infections, cancer) and improves your child's quality of life.

Atazanavir is used with other medications to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Atazanavir is not a cure for HIV or AIDS. 

DOSE:- 300mg OD with ritonavir 100mg taken at meal time . 

SIDE EFFECTS:-

Some medicines can cause unwanted or dangerous effects when used with atazanavir. Your doctor may need to change your treatment plan if you use:

alfuzosin;

cisapride;

irinotecan;

rifampin;

sildenafil (Revatio, for treating pulmonary arterial hypertension);

Atazanavir can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vaginal rings. To prevent pregnancy while using atazanavir, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.

:including in WHO model list of essential medicine March 2011(WHO