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ASPARAGINASE (L-ASPARAGINASE) ,(L-ASPase)

 ASPARAGINASE(L-ASPARAGINASE),(L-ASPase)


BRAND NAME:- LEUNASE,HOILASP 10,000 KU per vial inj .Elspar.




Asparaginase is an enzyme that is used as a medication and in food manufacturing. As a medication ,L-ASPase is an ANTI-CANCER and miscellaneous cytotoxic class of drug. Is used in treatment of acute lymphocyte leukaemia (ALL). It  worked by starving tumer cells of needed nutrents and slowing cell growth. 



PHARMACOLOGICAL & MECHANISM OF ACTION:-

This is enzyme was introduced on the basis of a different observed between normal cells and those from childhood Lymphoblastic leukaemia,viz . The leukaemia cells were found to be deficient in L- ASPARAGINASE synthase enzyme and depended on the supply of L-asparagine from the medium. The enzyme L-ASPase (from E.coli.) degrades L- ASPARAGINe to L - aspartic acid , depriving the leukaemia cells of an essential metabolite, and causes cell death. 

L-ASPase is a component of regimen for inducing remission in acute Lymphoblastic leukaemia along with Mtx., Prednisolone,vincristine , etc. However, resistance develops to L-ASPase mostly by induction of L- ASPARAGINe synthase in the leukaemic cells . More over , L-ASPase is antigenic, produces neutralizing antibodies which inactivate and clear the enzyme rapidly,so that clinical response is lost . A polyethylene glycol conjugated L-ASPase (peg-asparaginase) has been produced which has very slow clearance from the body ,is injected every 2 weeks and is more effective. It is also antigenic . 



USED:- Asparaginases can be used for different industrial and pharmaceutical purposes.

2.Treatment of Acute lymphocyte leukemia (ALL).


SIDE EFFECTS:-upset stomach or throwing up and some allergic reaction etc.


DOSE:-

50-200KU /Kg i.v., also i.m daily or twice weekly for 3-4 weeks.


:including in WHO model list of essential medicine March 2011(WHO





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