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ASCORBIC ACID (VITAMIN C)

 ASCORBIC ACID (VITAMIN C)


BRAND NAME:-Limcee, vitamin c etc.



ASCORBIC ACID is known as Vitamin c.



CHEMISTRY AND SOURCE:-

ASCORBIC ACID is a 6 carbon organic acid with structural similarly to glucose. It is a potent reducing agent and L- form is biologically active, citrus fruit (lemon, orange) and black currants are the richest source; others are tomato, potato, green chillies, cabbage and other vegetables. Human milk is richer in vit. C (25-50mg/L) than cows milk 



ABSORPTION AND FATE:- 

it is nearly completely absorbed from g.i.t. and widely distributed extra - and intracellularly. Plasma concentrations and total body store of vit c is realated to daily intake. The usual 60mg /day intake results in about 0.8 mg/dl in plasma and 1.5 g in the body as a whole. Increasing proportion are excreted in urine with higher intakes. Body is not able to store more than 2.5g .It is partly oxidized to active (dehydroascorbic acid ) and inactive (oxalic acid) metabolites.


PHYSIOLOGICAL ROLE AND ACTION:-

VIT. C plays a role in many oxidative and other metabolic reactions,e.g hydroxylation of proline and lysine residues of protocollagen - essential for formation and stabilization of collagen triple helix ; hydroxylation of carnitine , conversion of folic acid to folinic acid , biosynthesis of adrenal streoids , catecholamines , oxytocin and vasopressin and metabolism of cyclic nucleotides and prostaglandin. It directly stimulate collagen synthesis and is very important for maintenance of intercellular connective tissue. A number of ill- defined action have been ascribed to ascorbic acid in mega doses,but none is proven.


USED & DOSE

1. Prevention of ascorbic acid deficiency in individual at risk and infants : 59-100mg/day. Vit C or orange juice can be routinely included in infants diet.

2 . Treatment of scurvy - 0.5- 1.5 g/day.

3. Anemia 

4. Acidity urine (1g TDS - QID ) in urinary tract infection.

5. Other use chronic leg healing, required of vit c is increased in post injury periods.

6.  Large doses (2-6mg/day) of ASCORBIC ACID have been tried for a variety of purposes (common cold to cancer) with inconsistent results.


ADVERSE EFFECTS:-

ASCORBIC ACID is well tolerated in usual doses. Mega doses given for long periods can cause 'rebound scurvy' on stopage probably due to enhancement of its own metabolism or tissue acclimatization . The risk of urinary oxalate stones may be increased . High doses may also be cytotoxic when added to iron  preparation.




:In national essential medicine (2011), INDIA(I)


: including in WHO model list of essential medicine March 2011(WHO



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