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ARTESUNATE used, side effects, Dose & more.....

 ARTESUNATE


BRAND NAME:- FALICIGO, FALCYNATE, ARTINATE 50mg tab ,60mg / vial inj; LARTINATE ,ARNATE 50mg tab.

ARTESUNATE is an antimalarial and artemisinin Derivatives class of drug. Its sodium salt is water soluble and Artesunate was developed out of a need for a more hydrophilic derivative of artemisinin, use in initial treatment of severe malaria.


PHARMACODYNAMIC & MECHANISM OF ACTION:-

It's sodium salt is water - soluble and is administered by oral, i.m or i.v. route. In addition,rectal route has been tried. After oral ingestion, absorption is incomplete but fast , reaching peak in < 60min. It is rapidly converted to the active metabolite DHA with a t½ of 30-60 min. The t ½ of DHA is 1-2 hours . After repeated dosing, artesunate causes autoinduction of its own metabolism by CYP2B6 AND CYP3A4.

NOTE:-Data on PHARMACODYNAMICs of artemisinin Derivatives is limited and incomplete . ARTESUNATE are prodrug  


USED:-

Severe treatment of malaria 🦟.

like Uncomplicated falciparum malaria,vivax malaria, Severe and complicated falciparum malaria.


SIDE EFFECTS:-

Loss of appetite on days 1-2

Dizziness on days 1-2

Nausea on days 1-2

Diarrhea on days 1-2

Additional Side Effects of Artesunate can include:

Rash

Hemoglobinuria

Seizures

Neuropsychiatric reactions

Reversible neurologic change 


INTERACTION:- 

concurrent administration of artemisinin with drugs prolonging Q - T , like astemizole , antiarrhythmic, Tricycle antidepressant and phenothiazines may increase the risk of cardiac conduction defects. However,no Interference with the ACT partner drugs has been noted.

Dose:- As directed by your doctor.





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