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ARTESUNATE + SULFADOXINE + PYRIMETHAMINE (AS-S/P)

 ARTESUNATE + SULFADOXINE + PYRIMETHAMINE (AS-S/P)


BRAND NAME:- ZESUNATE kit, MASUNATE kit,FALCIART kit 



ARTESUNATE + SULFADOXINE + PYRIMETHAMINE (AS-S/P) ia an antimalarial Drug, groups of artemisinin Derivatives.

This ACT has been adopted as the first line drug for uncomplicated falciparum malaria under the 'National antimalarial Drug policy ' of India,and has replaced CQ throughout the country. This does not imply that it is the most effective/ best ACT , because it is not effective against multidrug - resistance strains which are non responsive to S/P . However, treatment failures with AS-S/P ACT are mostly restricted to Northeast areas bordering Myanmar; while in rest of INDIA so far this ACT appears to be working satisfactorily with > 96% success rate. As such ,NVBDCP continues to use AS-S/P ACT as the first line therapy, including that during 2nd 3rd trimester of pregnancy. This ACT appears to produce fewer side effects than artesunate/ mefloquine. Private clinic, however,are using other ACTs . Most other malaria endemic countries have found AS-S/P ACT to be interior.


USED:- 

Treatment of malaria.


DOSE:-

Artesunate 100mg BD (4mg/kg/day) × 3 days + SULFADOXINE 1500mg  (25mg/kg) and PYRIMETHAMINE 75 mg ( 1.25mg/kg) single dose.

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