AMLODIPINE

 AMLODIPINE

BRAND NAME:- AMLOPRES,AMCARD,AMLOPIN ,MYODURA 2.5,5,10mg tabs.

AMLODIPINE is a class of calcium channel blocker , Dihydropyridined group drug. These Dihydropyridined (DHPs) are most potent Ca²+ channel blocker, and this subclass has proliferated exceptionally . The common property of CCBs is to inhibit Ca²+ mediated slow channel components of action potential (AP) in smooth) / cardiac muscle cells. The two most important action of CCBs are:

1. Smooth muscle (especially vascular) relaxation.

2. Negative chronotropic ,inotropic and dromotropic action of heart.

Oral absorption is slow ,but complete; peak blood level occurs.after 6 to 9 hr -- the early vasodilator side effects (palpitation, flushing, headache, postural dizziness) are largely avoided. Because of less extensive and less variable first pass metabolism, its oral bioavailability is higher and more consistent. Volume of distribution and t½ are exceptionally long: diurnal fluctuation in blood level is small and action extends over the next morning.

USE:- Amlodipine is used to treat high blood pressure (hypertension), some types of angina and other conditions caused by coronary artery disease. Amlodipine is a calcium channel blocker that works by changing the movement of calcium in the heart and blood vessel cells. This widens the blood vessels which increases the blood and oxygen supply to the heart and also lowers blood pressure.

BEFORE TAKING THIS MEDICINE:-

You should not take amlodipine if you are allergic to it.

To make sure amlodipine is safe for you, tell your doctor if you have ever had:

liver disease; or

a heart valve problem called aortic stenosis.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether amlodipine will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.

Amlodipine can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.

Amlodipine is not approved for use by anyone younger than 6 years old.

SIDE EFFECTS:-

Get emergency medical help if you have signs of an allergic reaction to amlodipine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, when you first start taking amlodipine, your angina may get worse or you could have a heart attack. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

DOSE:- 5-10mg OD

S(-) AMLODIPINE THE SINGLE ENANTIOMER PREPARATION IS EFFECTIVE AT HALF THE DOSE AND IS CLAIMED TO CAUSE LESS ANKLE EDEMA.

DOSE:- 2.5-5mg OD

BRAND NAME:- S-NUMALO, S-AMCARD, ASOMEX,ESAM 2.5, 5mg tabs.

:In national of essential medicine (2011), INDIA(I)

: including in WHO model list of essential medicine March 2011(WHO)