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ALUMINIUM HYDROXIDE

 ALUMINIUM HYDROXIDE


BRAND NAME:-ALUDROX 0.84 g tab , 0.6g/ 10ml susp.


Aluminium hydroxide gel . It is a bland,weak and slowly reacting antacid. On keeping it slowly polymerizes to variable extents into still less reactive forms  . Thus, the ANC of a preparation gradually declines on storage. Also , the product from different manufacturers may have differing ANCs; usually it varies from 1-2.5mEq/g .Thus ,5ml of its suspension may neutralize just 1 mEq HCL . As such, little worthwhile acid neutralization is obtained at conventional doses.

The A1³+ ions relax smooth muscle. Thus ,it delay gastric emptying. Alum.hydrox. frequently,causes constipation due to its smooth muscle relaxant and mucosal astringent action.

Aluminium hydroxide binds phosphate in the intestine and prevent its absorption -- hypophosphatemia occurs on regular use. This may:(a) cause osteomalacia (b) be used therapeutically in hyperphosphatemia and phosphate stone.

Small amount of Al³+ that is absorbed is excreted by kidney. This is impaired in renal failure - aluminium toxicity (encephalopathy, osteoporosis) can occur.

USED:-Use an antacid, neutralize gastric acid and raise pH of gastric contents, peptic ulcers,Gastroesophageal reflux.used in heartburn.



DRUG INTERACTIONS :- BY raising gastric pH and by forming complexes,the non-absorbable antacid decreased the absorption of many drugs , especially tetracycline,iron,salts,fluoroquinolones,ketaconazole,H2blockers , diazepam, phenothiazines,indomethacin, phenytoin, isoniazid,ethambutol and nitrofurantoin. Stagger their administration by 2 hrs . The efficacy of nitrofurantoin is also reduced by alkalinization of urine.


: In national of essential medicine (2011), INDIA(I)

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