ALFACALCIDOL

 ALFACALCIDOL

BRAND NAME:- ONE ALPHA, ALPHA D3, ALHPADOL 0.25 and 1ug caps ALFACAL 0.25,0.5 ug caps.

ALFACALCIDOL is an analogue of vitamin D Used for supplementation in human and as a poultry feed additive .It is 1 alpha-OHD3— a prodrug that is rapidly hydroxylated in the liver to 1,25 (OH)2 D3 or calcitriol. 

Therefore,it does not require hydroxylation at position 1 which is the limiting step in the generation of active from of vit.D, and which takes place in the kidney. 

ALFACALCIDOL has a weaker impact on calcium metabolism and parathyroid hormone levels than calcitriol .

BIOAVAILABILITY ACTION:-

ALFACALCIDOL is orally active and clinically equally effective on long term basis to calcitriol. It's metabolic activation in liver does not pose a problem even in severe liver disease.

Repeated serum calcium measurements are essential for regulation of maintenance dose. Hypercalcaemia should be watched for and therapy promptly interrupted for few days when it develops.

USED:- it is effective in renal bone disease,vit D dependent rickets ,vit D resistant rickets ,hypoparathyroidism ,it is also being Used in osteoporosis

DOSE:- 1-2ug/day, children<20kg 0.5ug/ day.

SIDE EFFECTS:-Weakness,Fatigue,Sleepiness,Headache,Loss of appetite,Dry mouth,Metallic taste,Nausea,Vomiting etc.