ADEFOVIR DIPIVOXIL

 ADEFOVIR DIPIVOXIL

BRAND NAME:- ADESERA ,ADEFOVIR 10mg tab.

ADEFOVIR DIPIVOXIL is an anti-hepatitis virus / nonselective antiviral drug and adefovir is a monophosphate analogue of AMP which is active against HBV and some other DNA as well as RNA virus.

ABSORPTION & MECHANISM & PHARMACOLOGICAL ACTIONS:- 

ADEFOVIR is a monophosphate analogue of AMP which is active against HBV and some other DNA 🧬 as well as RNA viruses,but is used only for hepatitis caused by HBV. Esterases in the intestine and liver release the active drug during absorption to attain oral bioavailability of - 60% in terms of adefovir, which is then distributed in whole body water . On entering cells, adefovir is phosphorylated to the diphosphate which has high affinity for HBV DNA polymerase compared to host cell DNA polymerase.

  Ths is enzyme is inhibited and adefovir itself gets incorporated in the viral DNA resulting in termination of the DNA chain . adefovir is primarily excerted by the kidney. While it's plasma t½ is 7 hours , intracellular t½ of the diphosphate is upto 18 hours .

   Adefovir is indicated in chronic hepatitis B , including lamivudine - resistance cases and those having concurrent HIV infection. There is no cross resistance between adefovir and lamivudine. Clinical, biochemical (liver function tests) , histological, serological and virological response occurs in nearly 50% patients within 1 year. 

USED:- In treatment of chronic (HBV ) hepatitis B viruses infection.

DOSE:- 10mg/day 

SIDE EFFECTS:- sore throat, headache, weakness , abdominal pain and flu syndrome. Nephrotoxicity at higher doses, pre-existing renal insufficiency. Lactic acidosis is a risk in patients receiving ANTI- HIV drugs.