Skip to main content

ACAMPROSATE

 ACAMPROSATE


BRAND NAME:-. CAMPRAL & other brands available.



ACAMPROSATE is a medical use along with counseling to treat alcohol use disorders. Acamprosate is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal.When used alone, acamprosate is not an effective therapy for alcohol use disorder in most individuals;studies have found that acamprosate works best when used in combination with psychosocial support since the drug facilitates a reduction in alcohol consumption as well as full abstinence.


PHARMACOLOGICAL & MECHANISM OF ACTION:-

It is a weak NMDA -receptor antagonist with modest GABAa receptor agonistic activity that is being used in USA ,UK and Europe for maintenance therapy of alcohol abstinence. In conjunction with social and motivational therapy,it has been found to reduce relapse of the drinking behaviour. The efficacy of ACAMPROSATE in this regard is rated comparable to naltrexone . It should be started soon after withdrawing alcohol and then given continuously at a dose of 666mg 2-3 time a day . The 5-HT³ antagonist ondansetron and the antiepileptic topiramate have also shown some promise in treating alcoholism.


DOSE:- 666mg 2-3 times a day. 


SIDE EFFECTS:- loose motion,nausea, abdominal pain and itching.


USED:- treatment of alcoholism ,as a antiseptic and many other clinical use.



Labels:

Comments

Post a Comment

Popular posts from this blog

Know details about Dabigatran etexilate drug ?

 Dabigatran Etexilate 
Post a Comment
Read more

Chlorthalidone Uses, Side Effects, and More....

 Chlorthalidone  Brand name:- Hythalton 50,100mg , Hydrazide, Thalizide ( 12.5, 25) . Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Pharmacodynamic:- Not 🚫 available.  Pharmacokinetics:- Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. As with other thiazide diuretics, ch...
Post a Comment
Read more

Captopril Uses, Side Effects, and More

 Captopril Brand name:- Angiopril 25mg tab, Aceten, Captopril 12.5, 25mg tab. Captopril is an angiotensin converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently. Pharmacodynamic:-  Captopril, an ACE inhibitor, antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons w...
Post a Comment
Read more