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ACAMPROSATE

 ACAMPROSATE


BRAND NAME:-. CAMPRAL & other brands available.



ACAMPROSATE is a medical use along with counseling to treat alcohol use disorders. Acamprosate is thought to stabilize chemical signaling in the brain that would otherwise be disrupted by alcohol withdrawal.When used alone, acamprosate is not an effective therapy for alcohol use disorder in most individuals;studies have found that acamprosate works best when used in combination with psychosocial support since the drug facilitates a reduction in alcohol consumption as well as full abstinence.


PHARMACOLOGICAL & MECHANISM OF ACTION:-

It is a weak NMDA -receptor antagonist with modest GABAa receptor agonistic activity that is being used in USA ,UK and Europe for maintenance therapy of alcohol abstinence. In conjunction with social and motivational therapy,it has been found to reduce relapse of the drinking behaviour. The efficacy of ACAMPROSATE in this regard is rated comparable to naltrexone . It should be started soon after withdrawing alcohol and then given continuously at a dose of 666mg 2-3 time a day . The 5-HT³ antagonist ondansetron and the antiepileptic topiramate have also shown some promise in treating alcoholism.


DOSE:- 666mg 2-3 times a day. 


SIDE EFFECTS:- loose motion,nausea, abdominal pain and itching.


USED:- treatment of alcoholism ,as a antiseptic and many other clinical use.



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