BENZHEXOL ( Trihexyphenidyl) Uses, Side Effects, and More

 BENZHEXOL (Trihexyphenidyl)

BRAND NAME :- PACITANE,PARBENZ 2mg tab . 

BENZHEXOL is an antispasmodic drug used to treat stiffness, tremors, spasms, and poor muscle control. It is an agent of the antimuscarinic class and is often used in management of Parkinson's disease.  

PHARMACODYNAMIC:- 

BENZHEXOL (Trihexyphenidyl) is an antimuscarinic indicated as an adjunct in the treatment of parkinsonism or as a treatment for drug-induced extrapyramidal symptoms.It has a long duration of action as it does not need to be given every day.It has a wide therapeutic window, with acute toxicity being non fatal in doses as high as 300 mg. Patients should have their iridocorneal angle examined before and intraocular pressure monitored during therapy.Patients should be counselled regarding the risk of anhidrosis and hyperthermia. 

MECHANISM OF ACTION:- 

BENZHEXOL is a non-selective muscarinic acetylcholine receptor antagonist but binds with higher affinity to the M1 subtype. In vivo studies have shown that trihexyphenidyl demonstrates higher affinity for central muscarinic receptors located in the cerebral cortex and lower affinity for those located peripherally.Other studies suggest that trihexyphenidyl may modify nicotinic acetylcholine receptor neurotransmission, leading indirectly to enhanced dopamine release in the striatum.Although the anticholinergic has proven to be useful in the treatment of symptoms associated with Parkinson’s disease or other movement disorders, its mechanism of action has yet to be fully elucidated. 

USE:- 

Trihexyphenidyl (Benzhexol) is an anti-muscarinic muscle relaxant used as an antispasmodic drug for both movement disorder (dystonia) and for control of secretions (drooling) in children. In dystonia, Trihexyphenidyl (Benzhexol) relaxes dystonic, constantly tensed muscles and reduces dystonic movements. 

SIDE EFFECTS:-  

Some patients may experience drowsiness, dizziness or blurred vision.

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Very rarely, this medication may cause:

Confusion or agitation.

Hearing or seeing things that are actually not present.

Difficulty passing urine or a decrease in the amount of urine.

Fast or irregular heartbeat.

Eye pain.

 

DOSE:- 2-10mg / day , as directed by your doctor