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 Chlorpropamide Brand name:- DIABINESE  Chlorpropamide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.  Pharmacodynamic:-   Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide. Pharmacokinetics :-  Maximal plasma concentrations are reached 3 to 5 hours after quick and nearly complete (>90%) resorption from the gut. Plasma half life is 36 hours; the drug is effective for about 24 hours, longer than other sulfonylureas. A stable plasma level is only reached after three days of continuous application. 90% of the drug are bound to plasma proteins; at least two albumin binding sites exist. More than 99% of chlorpropamide are excreted unchanged via the kidneys. It is first filtrated in the glomeruli, then reabsorbed, and finally secrete...

 Chlormezanone Brand name:- Dolobak 100mg + paracetamol 450mg tab, Chlormezanone has antianxiety and hypnotic actions as well , and has been used for tension states associated with increased muscle tone.They work by blocking the release of certain chemical messengers in the brain that cause fever and pain respectively. Pharmacodynamic:-  Chlormezanone is a non- benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis). Mechanism of action:-  Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. Used:-  Used for muscular pain. Side effects:-  Nausea, Vomit...